LMPD Database

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LMP001329

UniProt Annotations

Entry Information
Gene Namehydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Protein Entry3BHS7_MOUSE
UniProt IDQ9EQC1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity3-beta-hydroxy-Delta(5)-steroid + NAD(+) = 3- oxo-Delta(5)-steroid + NADH.
Catalytic ActivityCholest-5-ene-3-beta,7-alpha-diol + NAD(+) = 7-alpha-hydroxycholest-4-en-3-one + NADH.
FunctionThe 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.
PathwayLipid metabolism; steroid biosynthesis.
SimilarityBelongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue SpecificityPredominantly expressed in liver. {ECO:0000269|PubMed:11067870}.