LMPD Database

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LMP001340

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol glycan anchor biosynthesis, class K
Protein EntryGPI8_HUMAN
UniProt IDQ92643
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92643-1; Sequence=Displayed; Name=2; IsoId=Q92643-2; Sequence=VSP_056457; Note=No experimental confirmation available.;
FunctionMediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
PtmThe disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.
SimilarityBelongs to the peptidase C13 family.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type I membrane protein .
SubunitForms a complex with PIGT, PIGS, PIGU and GAA1.