LMPD Database

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LMP001363

UniProt Annotations

Entry Information
Gene Nameleukotriene A4 hydrolase
Protein EntryLKHA4_MOUSE
UniProt IDP24527
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=5 uM for leukotriene A4 {ECO:0000269|PubMed:9287304}; Vmax=1030 nmol/min/mg enzyme for leukotriene A4 {ECO:0000269|PubMed:9287304};
Catalytic Activity(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate. {ECO:0000269|PubMed:9287304}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
Enzyme RegulationInhibited by bestatin. Subject to suicide inhibition by leukotriene A4. {ECO:0000269|PubMed:9287304}.
FunctionEpoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269|PubMed:9287304}.
PathwayLipid metabolism; leukotriene B4 biosynthesis.
PtmPhosphorylation at Ser-416 inhibits enzymatic activity. {ECO:0000250}.
SimilarityBelongs to the peptidase M1 family. {ECO:0000305}.
Subcellular LocationCytoplasm.