LMPD Database

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LMP001366

UniProt Annotations

Entry Information
Gene Namephospholipase D2
Protein EntryPLD2_HUMAN
UniProt IDO14939
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=PLD2A; IsoId=O14939-1; Sequence=Displayed; Name=PLD2C; IsoId=O14939-3; Sequence=VSP_005027; Name=PLD2B; IsoId=O14939-4; Sequence=VSP_054769;
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate and activated by the ADP-ribosylation factor-1 (ARF- 1).
FunctionMay have a role in signal-induced cytoskeletal regulation and/or endocytosis.
InteractionP23528:CFL1; NbExp=2; IntAct=EBI-1053996, EBI-352733; P62993:GRB2; NbExp=4; IntAct=EBI-1053996, EBI-401755;
PtmPhosphorylated by FGR.
SimilarityBelongs to the phospholipase D family.
SimilarityContains 1 PH domain.
SimilarityContains 1 PX (phox homology) domain.
SimilarityContains 2 PLD phosphodiesterase domains.
Subcellular LocationMembrane ; Peripheral membrane protein .
SubunitInteracts with EGFR (By similarity). Interacts with PIP5K1B.
Tissue SpecificityUbiquitous.
Web ResourceName=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";