LMPD Database

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LMP001405

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family A (ABC1), member 4
Protein EntryABCA4_MOUSE
UniProt IDO35600
SpeciesMouse
Comments
Comment typeDescription
Disruption PhenotypeDelayed dark adaptation but normal final rod threshold. {ECO:0000269|PubMed:10412977}.
FunctionIn the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery (By similarity). {ECO:0000250}.
SimilarityBelongs to the ABC transporter superfamily. ABCA family. {ECO:0000305}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMembrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. {ECO:0000250}.
Tissue SpecificityRetinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.