LMPD Database

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LMP001408

UniProt Annotations

Entry Information
Gene Namephospholipase C, beta 3
Protein EntryPLCB3_MOUSE
UniProt IDP51432
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular LocationNucleus {ECO:0000269|PubMed:9714794}.
SubunitInteracts with SHANK2 and LPAR2. {ECO:0000250}.
Tissue SpecificityHighly expressed in kidney, skeletal muscle, liver, lung, heart and brain.