LMPD Database

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LMP001477

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group I, member 3
Protein EntryNR1I3_MOUSE
UniProt IDO35627
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=CAR1; IsoId=O35627-1; Sequence=Displayed; Name=CAR2; IsoId=O35627-2; Sequence=VSP_003671, VSP_003672; Note=Does not seem to act as a transactivator. Lacks the C-terminal portion of the ligand binding/dimerization domain.;
DomainComposed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
FunctionBinds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). {ECO:0000250}.
PtmPhosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation. {ECO:0000250}.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7.
SubunitHeterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90. {ECO:0000269|PubMed:14573755, ECO:0000269|PubMed:15610733, ECO:0000269|PubMed:17904126, ECO:0000269|PubMed:8603043}.
Tissue SpecificityPredominantly expressed in liver.