LMPD Database

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LMP001516

UniProt Annotations

Entry Information
Gene Namephospholipase C-like 2
Protein EntryPLCL2_MOUSE
UniProt IDQ8K394
SpeciesMouse
Comments
Comment typeDescription
CautionIn the PI-PLC X-box Thr-487 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. {ECO:0000305}.
FunctionMay play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000269|PubMed:10581172}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
SimilarityContains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:10581172}. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.
Tissue SpecificityUbiquitously expressed, with a strong expression in skeletal muscle. {ECO:0000269|PubMed:10581172}.