LMPD Database

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LMP001524

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, alpha
Protein EntryDGKA_MOUSE
UniProt IDO88673
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationStimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C (By similarity). {ECO:0000250}.
FunctionUpon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. {ECO:0000250}.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
SubunitMonomer. {ECO:0000250}.