LMPD Database

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LMP001544

Record overview

LMPD IDLMP001544
Gene ID64577
SpeciesHomo sapiens (Human)
Gene Namealdehyde dehydrogenase 8 family, member A1
Gene SymbolALDH8A1
SynonymsALDH12; DJ352A20.2
Alternate namesaldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein
Chromosome6
Map Location6q23.2
EC Number1.2.1.-
SummaryThis protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
OrthologsView orthologs and multiple alignments for ALDH8A1

Proteins

aldehyde dehydrogenase family 8 member A1 isoform 1
Refseq ID:NP_072090
Protein GI:12007648
UniProt ID:Q9H2A2
mRNA ID:NM_022568
Length:487
RefSeq Status:REVIEWED
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLA
LARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVP
PGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY
SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVV
PFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH
 
aldehyde dehydrogenase family 8 member A1 isoform 2
Refseq ID:NP_739577
Protein GI:25952152
UniProt ID:Q9H2A2
mRNA ID:NM_170771
Length:433
RefSeq Status:REVIEWED
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLA
LARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVP
PGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWC
GEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELN
LPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH
 
aldehyde dehydrogenase family 8 member A1 isoform 3
Refseq ID:NP_001180409
Protein GI:301500698
UniProt ID:Q9H2A2
mRNA ID:NM_001193480
Length:437
RefSeq Status:REVIEWED
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLA
LARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKL
SLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGA
QIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLI
RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH