LMPD Database

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LMP001546

UniProt Annotations

Entry Information
Gene Nameneuraminidase 1
Protein EntryNEUR1_MOUSE
UniProt IDO35657
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
DomainA C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.
FunctionCatalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
PtmN-glycosylated. {ECO:0000305}.
PtmPhosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.
SimilarityBelongs to the glycosyl hydrolase 33 family. {ECO:0000305}.
SimilarityContains 4 BNR repeats. {ECO:0000305}.
Subcellular LocationLysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000269|PubMed:9384611}; Lumenal side {ECO:0000269|PubMed:9384611}. Lysosome lumen {ECO:0000269|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}. Cytoplasmic vesicle {ECO:0000269|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
SubunitInteracts with cathepsin A (protective protein), beta- galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
Tissue SpecificityHighly expressed in kidney, epididymis, followed by brain, spinal cord and weakly expressed in adrenal, heart, liver, lung and spleen. {ECO:0000269|PubMed:9384611}.