LMPD Database

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LMP001555

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member D1
Protein EntryAK1D1_MOUSE
UniProt IDQ8VCX1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone.
Catalytic Activity5-beta-cholestan-3-one + NADP(+) = cholest-4- en-3-one + NADPH.
FunctionEfficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.