LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001560

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein EntryP85B_HUMAN
UniProt IDO00459
SpeciesHuman
Comments
Comment typeDescription
DiseaseMegalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1) [MIM
DomainThe SH2 2 domain is required for interaction with FBXL2 and PTPN13.
FunctionRegulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
InteractionP10275:AR; NbExp=14; IntAct=EBI-346930, EBI-608057; P00533:EGFR; NbExp=3; IntAct=EBI-346930, EBI-297353; P04626:ERBB2; NbExp=6; IntAct=EBI-346930, EBI-641062; P21860:ERBB3; NbExp=16; IntAct=EBI-346930, EBI-720706; Q13480:GAB1; NbExp=23; IntAct=EBI-346930, EBI-517684; P62993:GRB2; NbExp=4; IntAct=EBI-346930, EBI-401755; P42858:HTT; NbExp=6; IntAct=EBI-346930, EBI-466029; P10721:KIT; NbExp=19; IntAct=EBI-346930, EBI-1379503; P08581:MET; NbExp=11; IntAct=EBI-346930, EBI-1039152; P03496:NS (xeno); NbExp=8; IntAct=EBI-346930, EBI-2547442; P42338:PIK3CB; NbExp=3; IntAct=EBI-346930, EBI-2609540;
PtmPhosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)- mediated polyubiquitination (PubMed:23604317). {ECO
PtmUbiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.
SimilarityBelongs to the PI3K p85 subunit family.
SimilarityContains 1 Rho-GAP domain. {ECO
SimilarityContains 1 SH3 domain. {ECO
SimilarityContains 2 SH2 domains. {ECO
SubunitHeterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:9600074, PubMed:15102829). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). {ECO