LMPD Database

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LMP001574

UniProt Annotations

Entry Information
Gene Namephospholipid transfer protein
Protein EntryPLTP_HUMAN
UniProt IDP55058
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P55058-1; Sequence=Displayed; Name=2; IsoId=P55058-2; Sequence=VSP_003050; Name=3; IsoId=P55058-3; Sequence=VSP_045877; Note=No experimental confirmation available.; Name=4; IsoId=P55058-4; Sequence=VSP_054028; Note=No experimental confirmation available.;
FunctionFacilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
SimilarityBelongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular LocationSecreted.
Tissue SpecificityWide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pltp/";