LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001603

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator-activated receptor gamma, coactivator 1 beta
Protein EntryPRGC2_HUMAN
UniProt IDQ86YN6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; Synonyms=PGC1beta-1a; IsoId=Q86YN6-1; Sequence=Displayed; Name=2; Synonyms=PGC1beta-2a; IsoId=Q86YN6-2; Sequence=VSP_019299; Name=3; Synonyms=PGC1beta-1b; IsoId=Q86YN6-3; Sequence=VSP_019301; Name=4; Synonyms=PGC1beta-2b; IsoId=Q86YN6-4; Sequence=VSP_019299, VSP_019301; Name=5; Synonyms=PERC-s; IsoId=Q86YN6-5; Sequence=VSP_019300; Note=Lacks LXXLL motif 1 and has a reduced ability to enhance the hormone-dependent activity of estrogen receptor alpha.; Name=6; IsoId=Q86YN6-6; Sequence=VSP_043374, VSP_019300; Note=No experimental confirmation available.;
DomainContains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
FunctionPlays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO
InductionRepressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.
PolymorphismVariation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.
SimilarityContains 1 RRM (RNA recognition motif) domain.
Subcellular LocationNucleus .
SubunitInteracts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR- alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1. {ECO
Tissue SpecificityUbiquitous with higher expression in heart, brain and skeletal muscle. {ECO