LMPD Database

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LMP001688

UniProt Annotations

Entry Information
Gene Nameenoyl-Coenzyme A delta isomerase 2
Protein EntryECI2_MOUSE
UniProt IDQ9WUR2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUR2-1; Sequence=Displayed; Name=2; IsoId=Q9WUR2-2; Sequence=VSP_037855;
Catalytic Activity(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
FunctionAble to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). {ECO:0000250}.
PtmAcetylation of Lys-60 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23806337}.
Sequence CautionSequence=AAH01983.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 1 ACB (acyl-CoA-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00573}.
SimilarityIn the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular LocationIsoform 1: Mitochondrion {ECO:0000250}.
Subcellular LocationIsoform 2: Peroxisome matrix {ECO:0000250}.