LMPD Database

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LMP001697

UniProt Annotations

Entry Information
Gene Namelipoprotein lipase
Protein EntryLIPL_MOUSE
UniProt IDP11152
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Developmental StageMaximum expression in adipose tissue during early development. In heart, low levels 6 days before birth increasing 278-fold as animals reach adulthood. {ECO:0000269|PubMed:2723548}.
FunctionThe primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250}.
PtmTyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. {ECO:0000250}.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250}.
SubunitHomodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interacts with GPIHBP1. {ECO:0000250, ECO:0000269|PubMed:17403372}.
Tissue SpecificityExpressed in liver, epididymal fat, heart, psoas muscle, lactating mammary gland, adrenal, lung, and ovary. Highest levels in heart and adrenal gland. {ECO:0000269|PubMed:2723548}.