LMPD Database

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LMP001710

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, kappa
Protein EntryDGKK_HUMAN
UniProt IDQ5KSL6
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationInhibited in response to H(2)O(2).
FunctionPhosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
PtmPhosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).
SimilarityBelongs to the eukaryotic diacylglycerol kinase family.
SimilarityContains 1 DAGKc domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers.
Subcellular LocationCytoplasm . Membrane ; Peripheral membrane protein .
SubunitDoes not form homooligomers.
Tissue SpecificityExpressed in testis, and to a lesser extent in placenta.