LMPD Database

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LMP001723

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 4
Protein EntryACOT4_HUMAN
UniProt IDQ8N9L9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=14 uM for succinyl-CoA ; KM=147 uM for glutaryl-CoA ; KM=3.4 uM for C14-acyl-CoA ; Vmax=581 nmol/min/mg enzyme toward succinyl-CoA ; Vmax=132 nmol/min/mg enzyme toward glutaryl-CoA ; Vmax=137 nmol/min/mg enzyme toward C14-acyl-CoA ;
Catalytic ActivityPalmitoyl-CoA + H(2)O = CoA + palmitate.
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
MiscellaneousHuman ACOT4 may have acquired the combined activities of mouse ACOT3, ACOT4, and ACOT5.
SimilarityBelongs to the C/M/P thioester hydrolase family.
Subcellular LocationPeroxisome .
Tissue SpecificityStrongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.