LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001786

UniProt Annotations

Entry Information
Gene Namelysophospholipase I
Protein EntryLYPA1_HUMAN
UniProt IDQ6IAQ1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75608-1; Sequence=Displayed; Name=2; IsoId=O75608-2; Sequence=VSP_009196; Note=No experimental confirmation available.;
Catalytic ActivityPalmitoyl-protein + H(2)O = palmitate + protein.
Enzyme RegulationInhibited by palmostatin-B, leading to impair depalmitoylating of Ras.
FunctionHydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. {ECO
Sequence CautionSequence=AAB88180.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Subcellular LocationCytoplasm .
SubunitHomodimer.