LMPD Database

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LMP001823

UniProt Annotations

Entry Information
Gene Name2-hydroxyacyl-CoA lyase 1
Protein EntryHACL1_MOUSE
UniProt IDQ9QXE0
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2-hydroxyphytanoyl-CoA = pristanal + formyl- CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
FunctionCatalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. {ECO:0000250}.
PathwayLipid metabolism; fatty acid metabolism.
SimilarityBelongs to the TPP enzyme family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000250}.
SubunitHomotetramer. {ECO:0000250}.