LMPD Database

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LMP001849

UniProt Annotations

Entry Information
Gene Namelecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Protein EntryO95237_HUMAN
UniProt IDO95237
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + retinol--[cellular- retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl- ester--[cellular-retinol-binding-protein].
DiseaseLeber congenital amaurosis 14 (LCA14) [MIM
Enzyme RegulationInhibited by all-trans-retinyl alpha- bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).
FunctionTransfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
InductionLRAT activity is up-regulated by dietary vitamin A. Under conditions of vitamin A depletion, LRAT expression in the liver is induced by retinoic acid (By similarity).
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the H-rev107 family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificityHepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain. {ECO