LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001858

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IVF
Protein EntryPA24F_MOUSE
UniProt IDQ50L41
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme RegulationStimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:15866882}.
FunctionCalcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine. {ECO:0000269|PubMed:15866882}.
Sequence CautionSequence=AAH39947.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to lysosomal membranes in a calcium-dependent fashion.
Tissue SpecificityStrongly expressed in thyroid, expressed at intermediate level in stomach and at very low level in large intestine and prostate. {ECO:0000269|PubMed:15866882}.