LMPD Database

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LMP001885

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member B1 (aldose reductase)
Protein EntryALDR_HUMAN
UniProt IDP15121
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAlditol + NAD(P)(+) = aldose + NAD(P)H.
Enzyme RegulationCys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.
FunctionCatalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
SimilarityBelongs to the aldo/keto reductase family.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO
Tissue SpecificityHighly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.