LMPD Database

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LMP002049

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group V
Protein EntryPA2G5_HUMAN
UniProt IDP39877
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0.;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO
CofactorName=Ca(2+); Xref=ChEBI
DiseaseFleck retina, familial benign (FRFB) [MIM
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
PtmThis enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
SimilarityBelongs to the phospholipase A2 family.
Subcellular LocationSecreted.
Tissue SpecificityHeart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level).
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g5/";