LMPD Database

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LMP002052

UniProt Annotations

Entry Information
Gene Namefatty acid binding protein 6, ileal
Protein EntryFABP6_HUMAN
UniProt IDP51161
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=P51161-1; Sequence=Displayed; Name=2; Synonyms=IBABP-L; IsoId=P51161-2; Sequence=VSP_038039;
DomainForms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
FunctionIleal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
InductionIsoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up- regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.
Sequence CautionSequence=AAH22489.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Subcellular LocationIsoform 1: Cytoplasm.
Subcellular LocationIsoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.
Tissue SpecificityIsoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.