LMPD Database

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LMP002122

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 7
Protein EntryBACH_HUMAN
UniProt IDO00154
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1; Synonyms=B, HBACHb; IsoId=O00154-1; Sequence=Displayed; Name=2; Synonyms=A-X, hBACHa-X; IsoId=O00154-2; Sequence=VSP_000152, VSP_000155, VSP_000156; Name=3; Synonyms=A-Xi, hBACHa-Xi; IsoId=O00154-3; Sequence=VSP_000152, VSP_000154; Name=4; Synonyms=A, hBACHa; IsoId=O00154-4; Sequence=VSP_000152; Note=Major isoform.; Name=5; Synonyms=C, hBACHc; IsoId=O00154-5; Sequence=VSP_000151; Name=6; Synonyms=D, hBACHd; IsoId=O00154-6; Sequence=VSP_000153; Name=7; IsoId=O00154-7; Sequence=VSP_047094;
Catalytic ActivityPalmitoyl-CoA + H(2)O = CoA + palmitate.
DomainBoth hydrolase domains are required for efficient activity.
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Sequence CautionSequence=AAB61211.1; Type=Frameshift; Positions=371; Evidence= ; Sequence=AAH17365.2; Type=Erroneous initiation; Evidence= ; Sequence=CAI19435.1; Type=Erroneous initiation; Evidence= ; Sequence=CAI19774.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 2 acyl coenzyme A hydrolase domains.
Subcellular LocationIsoform 1: Mitochondrion.
Subcellular LocationIsoform 4: Cytoplasm.
Subcellular LocationIsoform 5: Mitochondrion.
Subcellular LocationIsoform 6: Cytoplasm.
SubunitHomohexamer.
Tissue SpecificityIsoform 4 is expressed exclusively in brain.