LMPD Database

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LMP002224

UniProt Annotations

Entry Information
Gene Nameacyl-Coenzyme A dehydrogenase, short/branched chain
Protein EntryACDSB_MOUSE
UniProt IDQ9DBL1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron- transfer flavoprotein + H(+).
Catalytic ActivityAcyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionHas greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). {ECO:0000250}.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
SimilarityBelongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000305}.
SubunitHomotetramer. {ECO:0000250}.