LMPD Database

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LMP002300

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase family, member 11
Protein EntryACD11_HUMAN
UniProt IDQ709F0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q709F0-1; Sequence=Displayed; Name=2; IsoId=Q709F0-2; Sequence=VSP_021188; Name=3; IsoId=Q709F0-3; Sequence=VSP_021187;
Catalytic ActivityAcyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
CofactorName=FAD; Xref=ChEBI
FunctionAcyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.
Sequence CautionSequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the acyl-CoA dehydrogenase family.
Subcellular LocationPeroxisome . Mitochondrion . Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316.
SubunitHomodimer.
Tissue SpecificityWidely expressed with highest levels in brain followed by liver, heart and kidney.