LMPD Database

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LMP002362

UniProt Annotations

Entry Information
Gene Namedolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Protein EntryGPT_MOUSE
UniProt IDP42867
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
Developmental StageHighest activity is during the mid-phase of lactation.
Disruption PhenotypeMice die 4 to 5 days post-fertilization, just after implantation, suggesting that protein function and N- glycosylation are essential in early embryogenesis. {ECO:0000269|PubMed:10536042}.
Enzyme RegulationEnzyme activity is stimulated by phosphatidylglycerol and mannosylphosphoryldolichol and inhibited by tunicamycin.
FunctionCatalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.
PathwayProtein modification; protein glycosylation.
Rna EditingModified_positions=74 {ECO:0000269|PubMed:8043075}; Note=Partially edited.;
SimilarityBelongs to the glycosyltransferase 4 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.