LMPD Database

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LMP002380

UniProt Annotations

Entry Information
Gene Namecholine/ethanolamine phosphotransferase 1
Protein EntryCEPT1_HUMAN
UniProt IDQ9Y6K0
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=37 uM for CDP-choline {ECO
Catalytic ActivityCDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
Catalytic ActivityCDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
CofactorName=Mg(2+); Xref=ChEBI
FunctionCatalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Sequence CautionSequence=AAF61194.1; Type=Frameshift; Positions=276; Evidence= ;
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-I family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein .
Tissue SpecificityUbiquitously expressed.