LMPD Database

LMP002403

Gene Information

Entrez Gene ID	3155
Gene Name	3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Symbol	HMGCL
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005743	IEA:Ensembl	C	mitochondrial inner membrane
GO:0005759	NAS:UniProtKB	C	mitochondrial matrix
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0005777	IDA:UniProtKB	C	peroxisome
GO:0031406	IEA:Ensembl	F	carboxylic acid binding
GO:0000062	IEA:Ensembl	F	fatty-acyl-CoA binding
GO:0004419	IDA:UniProtKB	F	hydroxymethylglutaryl-CoA lyase activity
GO:0000287	IDA:UniProtKB	F	magnesium ion binding
GO:0030145	IDA:UniProtKB	F	manganese ion binding
GO:0046872	IDA:UniProtKB	F	metal ion binding
GO:0042803	IDA:UniProtKB	F	protein homodimerization activity
GO:0005102	IPI:UniProtKB	F	receptor binding
GO:0006637	IEA:Ensembl	P	acyl-CoA metabolic process
GO:0046950	TAS:Reactome	P	cellular ketone body metabolic process
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0046951	IDA:UniProtKB	P	ketone body biosynthetic process
GO:0006552	NAS:UniProtKB	P	leucine catabolic process
GO:0001889	IEA:Ensembl	P	liver development
GO:0007005	IEA:Ensembl	P	mitochondrion organization
GO:0051262	IDA:UniProtKB	P	protein tetramerization
GO:0070542	IEA:Ensembl	P	response to fatty acid
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0044281	TAS:Reactome	P	small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04146	Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_1464	Synthesis of Ketone Bodies