LMPD Database

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LMP002438

UniProt Annotations

Entry Information
Gene Namecarnitine palmitoyltransferase 1C
Protein EntryCPT1C_HUMAN
UniProt IDQ8TCG5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCG5-1; Sequence=Displayed; Name=2; IsoId=Q8TCG5-2; Sequence=VSP_010677; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCG5-3; Sequence=VSP_012457; Note=No experimental confirmation available.;
Catalytic ActivityPalmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine.
PathwayLipid metabolism; fatty acid beta-oxidation.
Sequence CautionSequence=BAB85068.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAD38561.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the carnitine/choline acetyltransferase family.
Subcellular LocationMitochondrion outer membrane ; Multi-pass membrane protein . Cell junction, synapse .
SubunitPeripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).
Tissue SpecificityExpressed predominantly in brain and testis.