LMPD Database

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LMP002502

UniProt Annotations

Entry Information
Gene Nameleukotriene C4 synthase
Protein EntryLTC4S_MOUSE
UniProt IDQ60860
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityLeukotriene C(4) = leukotriene A(4) + glutathione.
FunctionCatalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationNucleus outer membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHomotrimer. Interacts with ALOX5AP and ALOX5 (By similarity). {ECO:0000250}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:8706658}.