LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002521

UniProt Annotations

Entry Information
Gene Namesteroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Protein EntryS5A2_HUMAN
UniProt IDP31213
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimally active at acidic pHs.;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
DiseasePseudovaginal perineoscrotal hypospadias (PPSH) [MIM
FunctionConverts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
PolymorphismIndividuals with Thr-49 have an increased risk of prostate cancer. The enzyme with Thr-49 has a higher in vitro V(max) than the Ala-49 enzyme.
SimilarityBelongs to the steroid 5-alpha reductase family.
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed in high levels in the prostate and many other androgen-sensitive tissues.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/srd5a2/";
Web ResourceName=Wikipedia; Note=5-alpha reductase entry; URL="http://en.wikipedia.org/wiki/5_alpha_reductase";