LMPD Database

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LMP002537

UniProt Annotations

Entry Information
Gene Name1-acylglycerol-3-phosphate O-acyltransferase 4
Protein EntryPLCD_HUMAN
UniProt IDQ9NRZ5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRZ5-1; Sequence=Displayed; Name=2; IsoId=Q9NRZ5-2; Sequence=VSP_056928, VSP_056929; Note=No experimental confirmation available;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
FunctionConverts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
InteractionP46108:CRK; NbExp=1; IntAct=EBI-1754287, EBI-886;
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityWidely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus.