LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002556

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIE
Protein EntryPA2GE_HUMAN
UniProt IDQ9NZK7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO
CofactorName=Ca(2+); Xref=ChEBI
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
SimilarityBelongs to the phospholipase A2 family.
Subcellular LocationSecreted.
Tissue SpecificityRestricted to the brain, heart, lung, and placenta.