LMPD Database

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LMP002647

UniProt Annotations

Entry Information
Gene Nameacyl-CoA binding domain containing 3
Protein EntryGCP60_HUMAN
UniProt IDQ9H3P7
SpeciesHuman
Comments
Comment typeDescription
DomainThe GOLD domain is essential for giantin binding.
FunctionInvolved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity).
InteractionO91464:- (xeno); NbExp=21; IntAct=EBI-1791792, EBI-7587528; Q9UBF8:PI4KB; NbExp=4; IntAct=EBI-1791792, EBI-1053214; Q8BHN0:Ppm1l (xeno); NbExp=3; IntAct=EBI-1791792, EBI-7970002;
SimilarityContains 1 ACB (acyl-CoA-binding) domain.
SimilarityContains 1 GOLD domain. {ECO
Subcellular LocationGolgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side {ECO
SubunitInteracts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory subunit RI- alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity).
Tissue SpecificityUbiquitous, with highest expression in testis and ovary.