LMPD Database

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LMP002761

UniProt Annotations

Entry Information
Gene Namegalactose-3-O-sulfotransferase 1
Protein EntryG3ST1_MOUSE
UniProt IDQ9JHE4
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
Catalytic Activity3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate.
FunctionCatalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3-galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000269|PubMed:11917099}.
MiscellaneousMice homozygous for a null mutation of the CST gene display hindlimb weakness from week 6 of age and subsequently show a prenounced tremor and progressive ataxia. Myelin vacuolation is observed in the cerebellar white matter, diencephalon, brainstem and spinal anterior column. Male mice were infertile due to a blocked spermatogenesis.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the galactose-3-O-sulfotransferase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityExpressed in brain, testis, kidney, stomach, small intestine, liver, and lung. Not detected in heart, skeletal muscle, and spleen. {ECO:0000269|PubMed:10727929}.