LMPD Database

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LMP002766

UniProt Annotations

Entry Information
Gene Namelysophosphatidic acid receptor 2
Protein EntryLPAR2_HUMAN
UniProt IDQ9HBW0
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO
InteractionP13569:CFTR; NbExp=3; IntAct=EBI-765995, EBI-349854; Q15599:SLC9A3R2; NbExp=3; IntAct=EBI-765995, EBI-1149760;
MiscellaneousPubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.
Sequence CautionSequence=AAC27728.1; Type=Frameshift; Positions=348; Evidence= ;
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell surface . Cell membrane ; Multi-pass membrane protein . Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
SubunitInteracts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1. {ECO
Tissue SpecificityExpressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPAR2ID40406ch19p13.html";