LMPD Database

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LMP002770

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 2B, member 1
Protein EntryST2B1_HUMAN
UniProt IDO00204
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SULT2B1b, B; IsoId=O00204-1; Sequence=Displayed; Name=2; Synonyms=SULT2B1a, A; IsoId=O00204-2; Sequence=VSP_012510;
Biophysicochemical PropertiesKinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1mM MgCl2) {ECO
Catalytic Activity3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. {ECO
InteractionQ96Q35:ALS2CR12; NbExp=3; IntAct=EBI-749441, EBI-750451;
SimilarityBelongs to the sulfotransferase 1 family.
Subcellular LocationCytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.
Tissue SpecificityExpressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.