LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002796

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group X
Protein EntryPA2GX_HUMAN
UniProt IDO15496
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO
CofactorName=Ca(2+); Xref=ChEBI
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
SimilarityBelongs to the phospholipase A2 family.
Subcellular LocationSecreted.
Tissue SpecificityFound in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.