LMPD Database

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LMP002822

UniProt Annotations

Entry Information
Gene Nameestrogen receptor 2 (beta)
Protein EntryESR2_MOUSE
UniProt IDO08537
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Beta-1; IsoId=O08537-1; Sequence=Displayed; Name=2; Synonyms=Beta-2; IsoId=O08537-2; Sequence=VSP_003693; Name=3; Synonyms=Beta-5A; IsoId=O08537-4; Sequence=VSP_003696; Note=Corresponds to exons 5 and 6 deletion. {ECO:0000305|PubMed:9685228}; Name=4; IsoId=O08537-6; Sequence=VSP_042429, VSP_042430; Note=Corresponds to exon 5 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. {ECO:0000305|PubMed:9685228}; Name=5; IsoId=O08537-7; Sequence=VSP_042431, VSP_042432; Note=Corresponds to exon 6 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. {ECO:0000305|PubMed:9685228};
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionNuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.
InductionIsoforms 1 and 2 are down-regulated by 17-beta- estradiol. {ECO:0000269|PubMed:11878304}.
InteractionP01101:Fos; NbExp=2; IntAct=EBI-2526214, EBI-4288185;
PtmPhosphorylation at Ser-87 and Ser-105 recruits NCOA1. {ECO:0000269|PubMed:10230404, ECO:0000269|PubMed:10995228}.
Sequence CautionSequence=AAC17919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI41076.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI45330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAL15175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC35719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC35770.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus.
SubunitBinds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DYX1C1. Interacts with PRMT2 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis. {ECO:0000269|PubMed:9607809}.