LMPD Database

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LMP002855

UniProt Annotations

Entry Information
Gene NameST3 beta-galactoside alpha-2,3-sialyltransferase 3
Protein EntryQ9CZ48_MOUSE
UniProt IDQ9CZ48
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCMP-N-acetylneuraminate + beta-D-galactosyl- (1->4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D- glucosaminyl-glycoprotein.
Developmental StageDevelopmental regulation only occurs in liver, heart, kidney and spleen.
FunctionCatalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Tissue SpecificityFound in all tissues tested. High expression found in brain, liver, kidney, colon, heart and spleen.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST3Gal III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_644";