LMPD Database

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LMP002889

UniProt Annotations

Entry Information
Gene Namecellular retinoic acid binding protein II
Protein EntryRABP2_MOUSE
UniProt IDP22935
SpeciesMouse
Comments
Comment typeDescription
DomainForms a beta-barrel structure that accommodates hydrophobic ligands in its interior. {ECO:0000250}.
FunctionTransports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. {ECO:0000269|PubMed:10490651}.
InductionBy retinoic acid.
PtmSumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:10490651}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10490651}. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
SubunitInteracts with importin alpha (By similarity). Interacts with RXR and RARA. {ECO:0000250}.
Tissue SpecificityEmbryo and skin of adult mouse.