LMPD Database

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LMP002949

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Protein EntryP85B_MOUSE
UniProt IDO08908
SpeciesMouse
Comments
Comment typeDescription
DomainThe SH2 2 domain is required for interaction with FBXL2 and PTPN13. {ECO:0000250|UniProtKB:O00459}.
FunctionRegulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. {ECO:0000250|UniProtKB:O00459}.
InteractionO88665:Brd7; NbExp=4; IntAct=EBI-643570, EBI-643930; Q9JK42:Pdk2; NbExp=3; IntAct=EBI-643570, EBI-643530;
PtmPhosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-649 by PTPN13. Phosphorylation of Tyr-649 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination. {ECO:0000250|UniProtKB:O00459}.
PtmUbiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. {ECO:0000250|UniProtKB:O00459}.
SimilarityBelongs to the PI3K p85 subunit family. {ECO:0000305}.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
SimilarityContains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SubunitHeterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine- phosphorylated) (By similarity). Interacts with NYAP1, NYAP2 and MYO16 (PubMed:21946561). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex. Interacts with PTPN13; dephosphorylates PIK3R2 (By similarity). {ECO:0000250|UniProtKB:O00459, ECO:0000269|PubMed:21946561}.