LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002980

UniProt Annotations

Entry Information
Gene Namefatty acid amide hydrolase
Protein EntryFAAH1_MOUSE
UniProt IDO08914
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAnandamide + H(2)O = arachidonic acid + ethanolamine.
Catalytic ActivityOleamide + H(2)O = oleic acid + NH(3).
FunctionDegrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). {ECO:0000250}.
SimilarityBelongs to the amidase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.
SubunitHomodimer. {ECO:0000250}.