LMPD Database

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LMP003124

UniProt Annotations

Entry Information
Gene Namealcohol dehydrogenase 4 (class II), pi polypeptide
Protein EntryADH4_MOUSE
UniProt IDQ9QYY9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn alcohol + NAD(+) = an aldehyde or ketone + NADH.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
FunctionInvolved in the reduction of benzoquinones. {ECO:0000269|PubMed:10514444}.
MiscellaneousHas much lower enzymatic activity towards alcohols and aldehydes compared to human class II ADH. Strongly inhibited by omega-hydroxy fatty acids.
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitDimer. {ECO:0000269|PubMed:10970744}.
Tissue SpecificityLiver specific. {ECO:0000269|PubMed:10514444}.