LMPD Database

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LMP003172

UniProt Annotations

Entry Information
Gene Namemembrane bound O-acyltransferase domain containing 2
Protein EntryMBOA2_MOUSE
UniProt IDQ8BN01
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8R3I2-1; Sequence=Displayed; Name=2; IsoId=Q8R3I2-2; Sequence=VSP_022458; Name=3; IsoId=Q8R3I2-3; Sequence=VSP_022457, VSP_022459; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=5.3 uM for oleoyl-CoA (in the presence of LPC C16:0 as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=48.15 uM for oleoyl-CoA (in the presence of LPE C16:0 as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=7.9 uM for LPC C16:0 (in the presence of oleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18287005}; KM=27.7 uM for LPE C16:0 (in the presence of oleoyl-CoA as cosubstrate) {ECO:0000269|PubMed:18287005}; Vmax=24.24 nmol/min/mg enzyme with oleoyl-CoA and LPC C16:0 as substrates {ECO:0000269|PubMed:18287005}; Vmax=26.3 nmol/min/mg enzyme with oleoyl-CoA and LPE C16:0 as substrates {ECO:0000269|PubMed:18287005};
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18287005}.
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=BAC27567.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:18287005}.
Tissue SpecificityHighly expressed in epididymis, brain, testis, and ovary. {ECO:0000269|PubMed:18287005}.