LMPD Database

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LMP003186

UniProt Annotations

Entry Information
Gene Namephosphate cytidylyltransferase 1, choline, beta isoform
Protein EntryPCY1B_MOUSE
UniProt IDQ811Q9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CCTbeta2; IsoId=Q811Q9-1; Sequence=Displayed; Name=2; Synonyms=CCTbeta3; IsoId=Q811Q9-2; Sequence=VSP_020041, VSP_020042; Note=Enzymatic activity identical to isoform 1. Not expressed in embryo. Expression starts at 5 weeks.;
Catalytic ActivityCTP + phosphocholine = diphosphate + CDP- choline.
Developmental StageExpression is low at E7, reaches a maximum at E15 and decreases at E17. {ECO:0000269|PubMed:12842190}.
Disruption PhenotypeFemale mice lacking isoform 1 have reduced fecundity due to failure in ovary maturation. Male mice lacking isoform 1 have reduced fecundity due to testicular degeneration. {ECO:0000269|PubMed:15143167}.
FunctionControls phosphatidylcholine synthesis. {ECO:0000269|PubMed:12842190, ECO:0000269|PubMed:15143167}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Sequence CautionSequence=BAC27658.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the cytidylyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}.
Tissue SpecificityHighly expressed in brain (at protein level). Expressed at lower levels in lung and gonads. {ECO:0000269|PubMed:12842190, ECO:0000269|PubMed:15143167}.